PAPERS

近视：

  1. 在国际上首次发现角膜薄是近视的危险因素，并构建近视风险模型，是Journal of Ophthalmology杂志2024年被引用次数最多的文章，第一兼通讯作者：Zhou P, Wang DD, Fan L, Yang L, Zhao MW. Thin Central Corneal Thickness May Be a Risk Factor for Myopia Progression in Children. J Ophthalmol. 2023 Jan 16;2023:3815863.
  2. 在国际上首次发现近视的始动因素，是看近时睫状肌收缩将眼球拉长，通讯作者：Meng ZY, Yang L, Zhou P. Ciliary muscles contraction leads to axial length extension–The possible initiating factor for myopia. PLoS One. 2024 Apr 16;19(4):e0301844.
  3. 首次报道飞秒激光联合ICL人工晶状体治疗近视新技术，通讯作者：Meng ZY, Yang L, Zhou P. Femtosecond laser versus manual clear corneal incision in implantable collamer lens surgery. Sci Rep. 2025 Jan 7;15(1):1086. doi: 10.1038/s41598-024-81477-w.
  4. 发现了角膜塑形镜导致眼轴变短的生物力学机制，通讯作者：Meng ZY, Yang L, Zhou P. Analysis of axial shortening induced by orthokeratology lenses and its mechanical mechanisms. PLoS One. 2025 May 12;20(5):e0323546.
  5. 原创性地提出了一种客观视力计算方法，第一作者：Zhou P, Zhao MW, Li XX, Hu XF, Wu X, Niu LJ, Yu WZ, Xu XL. A new method of extrapolating the sweep pattern visual evoked potential acuity. Doc Ophthalmol. 2008 Sep;117(2):85-91.
  6. 单细胞测序研究了睫状肌收缩导致眼轴延长的细胞与分子机制，通讯作者.Zhao-Yang Meng; Chao Chen; Lin Yang; Xiang-Jia Zhu; Lei Fan; Peng Zhou. The role of Ciliary Muscle Contraction in Myopia Onset through Clinical, Animal, and Single-Cell RNA Sequencing Studies.
  7. 机器学习通过生物测量参数预测近视进展，第一作者Peng Zhou; Sitong Chen; Li Yingli; Li Yan. Machine Learning Prediction of Myopia Progression Using Ocular Biometric Parameters. Chinese Science Bulletin-Chinese.

视网膜疾病：

  1. 在国际上首次发现中心性浆液性视网膜脉络膜病变的致病基因，并列通讯作者：Jin EZ, Li TQ, Ren C, Zhu L, Du W, Qu JF, Yao YO, Li XX, Zhou P, Huang LZ, Zhao MW. An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci. 2022 Aug 2;63(9):9.
  2. 在国际上首次发现年龄相关性黄斑变性之玻璃膜疣的致病基因，并列通讯作者：Huang LZ, Li YJ, Xie XF, Zhang JJ, Cheng CY, Zhou P, Li XX: Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. Nature communications 2015, 6:6687.
  3. 首次阐明了黄斑变性致病基因的致病机制，该基因位点突变会导致该受体与双链RNA结合力降低一半：Zhou P, Fan L, Yu KD, Zhao MW, Li XX. Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. FASEB J. 2011 Oct;25(10):3489-95.
  4. 探索了晶状体对视网膜的保护作用视网膜联合在了一起，第一作者：Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton DR: Protection of retina by alphaB crystallin in sodium iodate induced retinal degeneration. PloS one 2014, 9(5):e98275.
  5. 合成siRNA治疗实验性增值性玻璃体视网膜疾病，第一作者：Zhou P, Zhao MW, Li XX, Yu WZ, Bian ZM. siRNA targeting mammalian target of rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy. Curr Eye Res. 2007 Nov;32(11):973-84.

晶状体与白内障：

  1. 在国际上首次发现第二只眼白内障手术更痛的分子机制，并命名该现象为“白内障术后交感性亚临床葡萄膜炎”，通讯作者：Zhu XJ, Wolff D, Zhang KK, He WW, Sun XH, Lu Y, Zhou P: Molecular Inflammation in the Contralateral Eye After Cataract Surgery in the First Eye. Investigative ophthalmology & visual science (IOVS) 2015, 56(9):5566-5573.
  2. 在国际上首次探索了白内障的表观遗传学改变，第一作者：Zhou P, Luo Y, Liu X, Fan L, Lu Y. Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataract. FASEB J. 2012 Dec;26(12):4897-902.
  3. 探索使用表观遗传调节药物治疗实验性白内障，第一作者：Zhou P, Lu Y, Sun XH. Effects of a novel DNA methyltransferase inhibitor Zebularine on human lens epithelial cells. Mol Vis. 2012;18:22-8.
  4. 再次探索使用表观遗传调节药物治疗实验性白内障，第一作者：Zhou P, Lu Y, Sun XH. Zebularine suppresses TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2. Mol Vis. 2011;17:2717-23.
  5. 筛查了晶状体蛋白的结合蛋白，并列通讯作者：Fan Q, Huang LZ, Zhu XJ, Zhang KK, Ye HF, Luo Y, Sun XH, Zhou P, Lu Y: Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Molecular vision 2014, 20:117-124.
  6. 继续研究白内障的表观遗传学改变，并列第一作者：Zhu XJ, Zhou P, Zhang KK, Yang J, Luo Y, Lu Y: Epigenetic regulation of alphaA-crystallin in high myopia-induced dark nuclear cataract. PloS one 2013, 8(12):e81900.
  7. 发现甲基化通过影响结合蛋白，进而影响晶状体蛋白基因转录。并列第一作者：Liu X, Zhou P, Fan F, Li D, Wu J, Lu Y, Luo Y: CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells. BMC ophthalmology 2016, 16:141.

肿瘤学：

  1. 发现TLR3是乳腺癌的致病基因，并列第一作者：Fan L, Zhou P, Hong Q, Chen AX, Liu GY, Yu KD, Shao ZM: Toll-like receptor 3 acts as a suppressor gene in breast cancer initiation and progression: a two-stage association study and functional investigation. Oncoimmunology 2019, 8(6):e1593801.
  2. 阐明了TLR3突变导致乳腺癌的机制是影响了该基因的转录，并列第一作者：Fan L, Zhou P, Chen AX, Liu GY, Yu KD, Shao ZM. Toll-like receptor 3 -926T>A increased the risk of breast cancer through decreased transcriptional activity. Oncoimmunology. 2019 Oct 15;8(12):e1673126.
  3. 使用临床数据与组织芯片验证了TLR3是乳腺癌的危险因素，并列通讯作者：Fan L, Sui XY, Jin X, Zhang WJ, Zhou P, Shao ZM. High expression of TLR3 in triple-negative breast cancer predicts better prognosis-data from the Fudan University Shanghai Cancer Center cohort and tissue microarrays. BMC Cancer. 2023 Apr 1;23(1):298.